Lonsdorf Lab Lab of Tina Lonsdorf

Tina’s academic journey began with studies in Psychology at the University of Trier and Justus Liebig University Giessen with a minor in Medicine, followed by a PhD in Clinical Neuroscience at Karolinska Institutet in Stockholm. She then moved to the University Medical Center Hamburg-Eppendorf, where she worked as a postdoc and later led her own research group within the Collaborative Research Center CRC 58 “Fear, Anxiety, Anxiety Disorders”. In 2013, Tina established the Emmy-Noether Research Group “Fear Profiles”, funded by the German Research Foundation. Since 2023, she has been Professor of Biological Psychology and Cognitive Neuroscience at Bielefeld University, while continuing her affiliation with the University Medical Center Hamburg-Eppendorf as a guest researcher. Tina is also actively involved in several collaborative initiatives: she’s a PI in the RTG “Emotional Learning and Memory” at the University of Hamburg and serves on the program committee of the DFG Priority Program “META-REP”. In addition, she chairs the Division of Biological Psychology and Neuropsychology within the German Psychological Society (DGPs).

Tina’s Papers:

2025

Assessing the Long-Term Stability of the Spielberger State-Trait Inventory Trait Scale over 3.5 Years
Maren Klingelhöfer-Jens, Franziska Reiser, Naemi D. Brandt, Dirk Schümann, Matthias Gamer, Raffael Kalisch, Tobias Sommer, Tina B. Lonsdorf
Journal of Personality Assessment  ·  24 Jun 2025  ·  doi:10.1080/00223891.2025.2513936
How Temporal Predictability of Threat and Action Preparation Affect Defensive Freezing Responses
Alina Koppold, Mana R Ehlers, Alexandros Kastrinogiannis, Felix H. Klaassen, Karin Roelofs, Tina B Lonsdorf
Center for Open Science  ·  28 Apr 2025  ·  doi:10.31234/osf.io/p84qz_v1
There is no research on a dead planet – Fostering ecologically sustainable open science practices in neuroscience
Lara Puhlmann, Alina Koppold, Gordon Feld, Tina B Lonsdorf, Kirsten Hilger, …, Matthias F.J. Sperl, Yu-Fang Yang, Laura Bechtold, Sebastian Ocklenburg, Helena Hartmann
Center for Open Science  ·  08 Apr 2025  ·  doi:10.31219/osf.io/rju75_v1

2024

The many faces of early life adversity - Content overlap in validated assessment instruments as well as in fear and reward learning research
Alina Koppold, Julia Ruge, Tobias Hecker, Tina Lonsdorf
Meta-Psychology  ·  07 Aug 2024  ·  doi:10.15626/MP.2023.3958
How adverse childhood experiences get under the skin: A systematic review, integration and methodological discussion on threat and reward learning mechanisms
Julia Ruge, Mana R Ehlers, Alexandros Kastrinogiannis, Maren Klingelhöfer-Jens, Alina Koppold, Rany Abend, Tina B Lonsdorf
eLife  ·  16 Jul 2024  ·  doi:10.7554/eLife.92700
Neuropsychobiology of fear-induced bradycardia in humans: progress and pitfalls
Simone Battaglia, Claudio Nazzi, Tina B. Lonsdorf, Julian F. Thayer
Molecular Psychiatry  ·  11 Jun 2024  ·  doi:10.1038/s41380-024-02600-x
How to Measure Fear Generalization? Reliability and Validity of Commonly Used Indices
Yannik Stegmann, Mario Reutter, Katharina Hutterer, Lea Hildebrandt, Jürgen Deckert, …, Dirk Schümann, Miriam Schiele, Peter Zwanzger, Marta Andreatta, Matthias Gamer
Center for Open Science  ·  17 May 2024  ·  doi:10.31234/osf.io/fk26y

2023

Bad days build better days: mental health improvement after the COVID-19 pandemic in individuals with psychosocial distress
Mario Reutter, Katharina Hutterer, Marthe Gründahl, Dominik Gall, Udo Dannlowski, …, Miriam Schiele, Peter Zwanzger, Paul Pauli, Grit Hein, Matthias Gamer
Springer Science and Business Media LLC  ·  11 Oct 2023  ·  doi:10.21203/rs.3.rs-3410491/v1
Within-subject reliability, occasion specificity, and validity of fluctuations of the Stroop and Go/No-Go tasks in ecological momentary assessment
Justin Hachenberger, Axel Mayer, Denny Kerkhoff, Friederike Eyssel, Stefan Fries, Tina B Lonsdorf, Hilmar G Zech, Lorenz Deserno, Sakari Lemola
Center for Open Science  ·  18 Sep 2023  ·  doi:10.31234/osf.io/g6qku
Recent advances in studying brain‐behavior interactions using functional imaging: The primary startle response pathway and its affective modulation in humans
Julia Wendt, Manuel Kuhn, Alfons O. Hamm, Tina B. Lonsdorf
Psychophysiology  ·  04 Jul 2023  ·  doi:10.1111/psyp.14364
Prediction of Changes in Negative Affect During the COVID-19 Pandemic by Experimental Fear Conditioning and Generalization Measures
Celina Imholze, Katharina Hutterer, Dominik Gall, Udo Dannlowski, Katharina Domschke, …, Karoline Rosenkranz, Miriam A. Schiele, Peter Zwanzger, Paul Pauli, Matthias Gamer
Zeitschrift für Psychologie  ·  01 May 2023  ·  doi:10.1027/2151-2604/a000523
Systematically investigating the role of context on effect replicability in reinstatement of fear in humans
R. Sjouwerman, T.B. Lonsdorf
Behaviour Research and Therapy  ·  01 Mar 2023  ·  doi:10.1016/j.brat.2023.104256
Quality research needs good working conditions
Rima-Maria Rahal, Susann Fiedler, Adeyemi Adetula, Ronnie P.-A. Berntsson, Ulrich Dirnagl, …, Tina B. Lonsdorf, Felix Schönbrodt, Miguel Alejandro A. Silan, Michael Wenzler, Flávio Azevedo
Nature Human Behaviour  ·  08 Feb 2023  ·  doi:10.1038/s41562-022-01508-2
Watching with Argus eyes: Characterization of emotional and physiological responding in adults exposed to childhood maltreatment and/or recent adversity
Alina Koppold, Alexandros Kastrinogiannis, Manuel Kuhn, Tina B. Lonsdorf
Psychophysiology  ·  02 Feb 2023  ·  doi:10.1111/psyp.14253

2022

Robust group- but limited individual-level (longitudinal) reliability and insights into cross-phases response prediction of conditioned fear
Maren Klingelhöfer-Jens, Mana R Ehlers, Manuel Kuhn, Vincent Keyaniyan, Tina B Lonsdorf
eLife  ·  13 Sep 2022  ·  doi:10.7554/eLife.78717
Data sharing in experimental fear and anxiety research: From challenges to a dynamically growing database in 10 simple steps
Mana R Ehlers, Tina B Lonsdorf
Center for Open Science  ·  22 Jul 2022  ·  doi:10.31234/osf.io/8crk3
A data multiverse analysis investigating non‐model based SCR quantification approaches
Rachel Sjouwerman, Sabrina Illius, Manuel Kuhn, Tina B. Lonsdorf
Psychophysiology  ·  02 Jul 2022  ·  doi:10.1111/psyp.14130
Multiverse analyses in fear conditioning research
Tina B. Lonsdorf, Anna Gerlicher, Maren Klingelhöfer-Jens, Angelos-Miltiadis Krypotos
Behaviour Research and Therapy  ·  01 Jun 2022  ·  doi:10.1016/j.brat.2022.104072
Recent advances in studying brain-behaviour interactions using functional imaging: The primary startle response pathway and its affective modulation in humans
Julia Wendt, Manuel Kuhn, Alfons O. Hamm, Tina B Lonsdorf
Center for Open Science  ·  13 May 2022  ·  doi:10.31234/osf.io/gtasm
Open and reproducible science practices in psychoneuroendocrinology: opportunities to foster scientific progress
Maria Meier, Tina B Lonsdorf, Sonia Lupien, Tobias Stalder, Sebastian Tristan Laufer, Maurizio Sicorello, Roman Linz, Lara Puhlmann
Center for Open Science  ·  30 Mar 2022  ·  doi:10.31234/osf.io/d2zvc

2021

Effects of intolerance of uncertainty on subjective and psychophysiological measures during fear acquisition and delayed extinction
Maren Klingelhöfer-Jens, Jayne Morriss, Tina B Lonsdorf
Center for Open Science  ·  25 Nov 2021  ·  doi:10.31234/osf.io/hj5gt
Mehr als nur fragwürdig: Reproduzierbarkeit und Open Science in der Lehre aus Sicht der Biologischen Psychologie und Neuropsychologie
Tina B Lonsdorf, Gesa Hartwigsen, Andrea Kübler, Christian J. Merz, Barbara Schmidt, Matthias F.J. Sperl, Gordon Feld
Center for Open Science  ·  08 Sep 2021  ·  doi:10.31234/osf.io/cp52v

2020

Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review
Mana R. Ehlers, Janne Nold, Manuel Kuhn, Maren Klingelhöfer-Jens, Tina B. Lonsdorf
Scientific Reports  ·  16 Nov 2020  ·  doi:10.1038/s41598-020-76683-1
Experimental boundary conditions of reinstatement‐induced return of fear in humans: Is reinstatement in humans what we think it is?
Rachel Sjouwerman, Tina B. Lonsdorf
Psychophysiology  ·  19 Feb 2020  ·  doi:10.1111/psyp.13549

2019

Navigating the garden of forking paths for data exclusions in fear conditioning research
Tina B Lonsdorf, Maren Klingelhöfer-Jens, Marta Andreatta, Tom Beckers, Anastasia Chalkia, …, Gaetan Mertens, Jan Richter, Rachel Sjouwerman, Julia Wendt, Christian J Merz
eLife  ·  16 Dec 2019  ·  doi:10.7554/eLife.52465
Experimental boundary conditions of reinstatement induced return of fear in humans: Is reinstatement in humans what we think it is?
Rachel Sjouwerman, Tina B Lonsdorf
Center for Open Science  ·  03 Dec 2019  ·  doi:10.31234/osf.io/4myk8
Fear Extinction Retention: Is It What We Think It Is?
Tina B. Lonsdorf, Christian J. Merz, Miquel A. Fullana
Biological Psychiatry  ·  01 Jun 2019  ·  doi:10.1016/j.biopsych.2019.02.011
The neurofunctional basis of affective startle modulation in humans – evidence from combined facial EMG-fMRI
Manuel Kuhn, Julia Wendt, Rachel Sjouwerman, Christian Büchel, Alfons Hamm, Tina B. Lonsdorf
Cold Spring Harbor Laboratory  ·  05 Mar 2019  ·  doi:10.1101/567032
Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes
Michael G. Gottschalk, Jan Richter, Christiane Ziegler, Miriam A. Schiele, Julia Mann, …, Andreas Reif, Jürgen Deckert, Susanne Neufang, Michael Höfler, Katharina Domschke
Translational Psychiatry  ·  04 Feb 2019  ·  doi:10.1038/s41398-019-0415-8

2018

Latency of skin conductance responses across stimulus modalities
R. Sjouwerman, T. B. Lonsdorf
Psychophysiology  ·  21 Nov 2018  ·  doi:10.1111/psyp.13307
Does US expectancy mediate the additive effects of CS-US pairings on contingency instructions? Results from subjective, psychophysiological and neural measures
Gaëtan Mertens, Senne Braem, Manuel Kuhn, Tina B. Lonsdorf, Marcel A. van den Hout, Iris M. Engelhard
Behaviour Research and Therapy  ·  01 Nov 2018  ·  doi:10.1016/j.brat.2018.09.003
Visual Complexity and Affect: Ratings Reflect More Than Meets the Eye
Christopher R. Madan, Janine Bayer, Matthias Gamer, Tina B. Lonsdorf, Tobias Sommer
Frontiers in Psychology  ·  18 Jan 2018  ·  doi:10.3389/fpsyg.2017.02368

2017

An elevated plus-maze in mixed reality for studying human anxiety-related behavior
Sarah V. Biedermann, Daniel G. Biedermann, Frederike Wenzlaff, Tim Kurjak, Sawis Nouri, …, Klaus Wiedemann, Peer Briken, Jan Haaker, Tina B. Lonsdorf, Johannes Fuss
BMC Biology  ·  01 Dec 2017  ·  doi:10.1186/s12915-017-0463-6
Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach.
U Lueken, M Kuhn, Y Yang, B Straube, T Kircher, …, H Weber, A Reif, K Domschke, J Deckert, T B Lonsdorf
Translational psychiatry  ·  05 Sep 2017  ·  pmid:28872638
Effects of an Anxiety-Specific Psychometric Factor on Fear Conditioning and Fear Generalization
Christian Baumann, Miriam A. Schiele, Martin J. Herrmann, Tina B. Lonsdorf, Peter Zwanzger, Katharina Domschke, Andreas Reif, Jürgen Deckert, Paul Pauli
Zeitschrift für Psychologie  ·  01 Jul 2017  ·  doi:10.1027/2151-2604/a000304
Don't fear 'fear conditioning': Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear.
Tina B Lonsdorf, Mareike M Menz, Marta Andreatta, Miguel A Fullana, Armita Golkar, …, Benjamin Straube, Bram Vervliet, Julia Wendt, Johanna M P Baas, Christian J Merz
Neuroscience and biobehavioral reviews  ·  03 Mar 2017  ·  pmid:28263758
GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder.
J Deckert, H Weber, C Villmann, T B Lonsdorf, J Richter, …, M M Nöthen, M Romanos, K Domschke, P Pauli, A Reif
Molecular psychiatry  ·  07 Feb 2017  ·  pmid:28167838
Where There is Smoke There is Fear-Impaired Contextual Inhibition of Conditioned Fear in Smokers.
Jan Haaker, Tina B Lonsdorf, Dirk Schümann, Nico Bunzeck, Jan Peters, Tobias Sommer, Raffael Kalisch
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  ·  25 Jan 2017  ·  pmid:28120933

2016

Don't startle me-Interference of startle probe presentations and intermittent ratings with fear acquisition.
Rachel Sjouwerman, Johanna Niehaus, Manuel Kuhn, Tina B Lonsdorf
Psychophysiology  ·  15 Sep 2016  ·  pmid:27628268
State anxiety modulates the return of fear.
Manuel Kuhn, Gaetan Mertens, Tina B Lonsdorf
International journal of psychophysiology : official journal of the International Organization of Psychophysiology  ·  03 Aug 2016  ·  pmid:27496367
Converging evidence for an impact of a functional NOS gene variation on anxiety-related processes.
Manuel Kuhn, Jan Haaker, Evelyn Glotzbach-Schoon, Dirk Schümann, Marta Andreatta, …, Andreas Mühlberger, Paul Pauli, Andreas Reif, Raffael Kalisch, Tina B Lonsdorf
Social cognitive and affective neuroscience  ·  08 Jan 2016  ·  pmid:26746182

2015

Contextual Change After Fear Acquisition Affects Conditioned Responding and the Time Course of Extinction Learning-Implications for Renewal Research.
Rachel Sjouwerman, Johanna Niehaus, Tina B Lonsdorf
Frontiers in behavioral neuroscience  ·  08 Dec 2015  ·  pmid:26696855
Neural correlates of and processes underlying generalized and differential return of fear.
Robert Scharfenort, Tina B Lonsdorf
Social cognitive and affective neuroscience  ·  25 Nov 2015  ·  pmid:26612681
Mismatch or allostatic load? Timing of life adversity differentially shapes gray matter volume and anxious temperament.
Manuel Kuhn, Robert Scharfenort, Dirk Schümann, Miriam A Schiele, Anna L Münsterkötter, …, Paul Pauli, Andreas Reif, Marcel Romanos, Peter Zwanzger, Tina B Lonsdorf
Social cognitive and affective neuroscience  ·  13 Nov 2015  ·  pmid:26568620
Sex differences in conditioned stimulus discrimination during context-dependent fear learning and its retrieval in humans: the role of biological sex, contraceptives and menstrual cycle phases.
Tina B Lonsdorf, Jan Haaker, Dirk Schümann, Tobias Sommer, Janine Bayer, Stefanie Brassen, Nico Bunzeck, Matthias Gamer, Raffael Kalisch
Journal of psychiatry & neuroscience : JPN  ·  01 Nov 2015  ·  pmid:26107163
Deficient inhibitory processing in trait anxiety: Evidence from context-dependent fear learning, extinction recall and renewal.
J Haaker, T B Lonsdorf, D Schümann, M Menz, S Brassen, N Bunzeck, M Gamer, R Kalisch
Biological psychology  ·  26 Jul 2015  ·  pmid:26219601
Effects of post-extinction l-DOPA administration on the spontaneous recovery and reinstatement of fear in a human fMRI study.
Jan Haaker, Tina B Lonsdorf, Raffael Kalisch
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology  ·  21 Jul 2015  ·  pmid:26238968
Fear expression and return of fear following threat instruction with or without direct contingency experience.
Gaëtan Mertens, Manuel Kuhn, An K Raes, Raffael Kalisch, Jan De Houwer, Tina B Lonsdorf
Cognition & emotion  ·  12 May 2015  ·  pmid:25966279
MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits.
Leif Hommers, Annette Raab, Alexandra Bohl, Heike Weber, Claus-Jürgen Scholz, …, Klaus-Peter Lesch, Katharina Domschke, Andreas Reif, Martin J Lohse, Jürgen Deckert
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics  ·  02 Apr 2015  ·  pmid:25847876

2014

A review on human reinstatement studies: an overview and methodological challenges.
Jan Haaker, Armita Golkar, Dirk Hermans, Tina B Lonsdorf
Learning & memory (Cold Spring Harbor, N.Y.)  ·  15 Aug 2014  ·  pmid:25128533
BDNFval66met affects neural activation pattern during fear conditioning and 24 h delayed fear recall.
Tina B Lonsdorf, Armita Golkar, Kara M Lindström, Jan Haaker, Arne Öhman, Martin Schalling, Martin Ingvar
Social cognitive and affective neuroscience  ·  07 Aug 2014  ·  pmid:25103087
Attention biases and habituation of attention biases are associated with 5-HTTLPR and COMTval158met.
Tina B Lonsdorf, Pernilla Juth, Christin Rohde, Martin Schalling, Arne Öhman
Cognitive, affective & behavioral neuroscience  ·  01 Mar 2014  ·  pmid:23943515
Higher anxiety and larger amygdala volumes in carriers of a TMEM132D risk variant for panic disorder.
J Haaker, T B Lonsdorf, K A Raczka, M-L Mechias, N Gartmann, R Kalisch
Translational psychiatry  ·  04 Feb 2014  ·  pmid:24495968
Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples.
Tina B Lonsdorf, Jan Haaker, Raffael Kalisch
Social cognitive and affective neuroscience  ·  03 Feb 2014  ·  pmid:24493848

2013

No evidence for enhanced extinction memory consolidation through noradrenergic reuptake inhibition-delayed memory test and reinstatement in human fMRI.
Tina B Lonsdorf, Jan Haaker, Tahmine Fadai, Raffael Kalisch
Psychopharmacology  ·  06 Nov 2013  ·  pmid:24193372
Multimodal assessment of long-term memory recall and reinstatement in a combined cue and context fear conditioning and extinction paradigm in humans.
Jan Haaker, Tina B Lonsdorf, Alexandra Thanellou, Raffael Kalisch
PloS one  ·  07 Oct 2013  ·  pmid:24116095
Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear.
Jan Haaker, Stefano Gaburro, Anupam Sah, Nina Gartmann, Tina B Lonsdorf, Kolja Meier, Nicolas Singewald, Hans-Christian Pape, Fabio Morellini, Raffael Kalisch
Proceedings of the National Academy of Sciences of the United States of America  ·  10 Jun 2013  ·  pmid:23754384

2012

Distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation.
Armita Golkar, Tina B Lonsdorf, Andreas Olsson, Kara M Lindstrom, Jonathan Berrebi, Peter Fransson, Martin Schalling, Martin Ingvar, Arne Öhman
PloS one  ·  07 Nov 2012  ·  pmid:23144849

2011

Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.
Fredrik Lindstedt, Jonathan Berrebi, Erik Greayer, Tina B Lonsdorf, Martin Schalling, Martin Ingvar, Eva Kosek
PloS one  ·  28 Mar 2011  ·  pmid:21464942
Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.
Fredrik Lindstedt, Tina B Lonsdorf, Martin Schalling, Eva Kosek, Martin Ingvar
PloS one  ·  15 Mar 2011  ·  pmid:21423614
5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation.
Tina B Lonsdorf, Armita Golkar, Kara M Lindstöm, Peter Fransson, Martin Schalling, Arne Ohman, Martin Ingvar
Biological psychology  ·  26 Feb 2011  ·  pmid:21356267

2010

The COMTval158met polymorphism is associated with symptom relief during exposure-based cognitive-behavioral treatment in panic disorder.
Tina B Lonsdorf, Christian Rück, Jan Bergström, Gerhard Andersson, Arne Ohman, Nils Lindefors, Martin Schalling
BMC psychiatry  ·  26 Nov 2010  ·  pmid:21110842
Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism.
Tina B Lonsdorf, Almut I Weike, Armita Golkar, Martin Schalling, Alfons O Hamm, Arne Öhman
Behavioral neuroscience  ·  01 Feb 2010  ·  pmid:20141276

2009

The symptomatic profile of panic disorder is shaped by the 5-HTTLPR polymorphism.
Tina B Lonsdorf, Christian Rück, Jan Bergström, Gerhard Andersson, Arne Ohman, Martin Schalling, Nils Lindefors
Progress in neuro-psychopharmacology & biological psychiatry  ·  12 Aug 2009  ·  pmid:19683026
Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans.
Eva Kosek, Karin B Jensen, Tina B Lonsdorf, Martin Schalling, Martin Ingvar
Molecular pain  ·  01 Jul 2009  ·  pmid:19570226
Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism.
Karin B Jensen, Tina B Lonsdorf, Martin Schalling, Eva Kosek, Martin Ingvar
PloS one  ·  23 Jun 2009  ·  pmid:19547755
Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder.
Tina B Lonsdorf, Almut I Weike, Pernilla Nikamo, Martin Schalling, Alfons O Hamm, Arne Ohman
Psychological science  ·  23 Jan 2009  ·  pmid:19175757

2006

Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward.
Peter Kirsch, Martin Reuter, Daniela Mier, Tina Lonsdorf, Rudolf Stark, Bernd Gallhofer, Dieter Vaitl, Jürgen Hennig
Neuroscience letters  ·  08 Aug 2006  ·  pmid:16901644

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